DARPin Targeted Magnetic Hyperthermic Therapy for
Glioblastoma
FP7
 
   Partner:
micromod Partikeltechnologie GmbH

Project Leader
Dr. Cordula Grüttner

Group Members
Dr. Joachim Teller
Dr. Fritz Westphal
Dr. Marianne Teller




Selected publications


DeNardo, S.J., et al., Thermal dosimetry predictive of efficacy of 111In-ChL6 nanoparticle AMF–induced thermoablative therapy for human breast cancer in mice. Medicine 2007. 48(3): p. 437-444

Bordelon, D.E., et al., Magnetic nanoparticle heating efficiency reveals magneto-structural differences when characterized with wide ranging and high amplitude alternating magnetic fields. Journal of Applied Physics 2011. 109(12): p. 124904

Grüttner, C., et al., Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy. Magn. Magn. Mat. 2007. 311(1): p. 181-186

Grüttner, C., et al., Synthesis and functionalisation of magnetic nanoparticles for hyperthermia applications. International Journal of Hyperthermia 2013. 29(8): p. 777-789

Hedayati, M., et al., The effect of cell-cluster size on intracellular nanoparticle-mediated hyperthermia: is it possible to treat microscopic tumors. Nanomedicine 2012. 8(1): p. 29-41

Dennis, C., et al., Nearly complete regression of tumors via collective behavior of magnetic nanoparticles in hyperthermia. Nanotechnology 2009. 20(39): p. 395103


 
Introduction

Modern particle applications make high demands on functionality and quality with regard to substrate fixation, separation and detection. Micromod′s customers are predominantly producers of diagnostic kits and high-throughput equipment, biotechnology companies, and various research institutions.

For that reason the micromod Partikeltechnologie GmbH offers a wide collection of nano- and microparticles that are characterized by a modular design.

20 years of experience in the production of chemically surface-functionalized and/or magnetizable micro- and nanoparticles and a continuously improved quality management are the basis for our comprehensive product range.

The main product categories are nanomag® (magnetic polysaccharide particles), micromer® (polystyrene-copolymer particles) and sicastar® (silica particles). They are available with many different functional properties and particle diameters. These particle types are complimented by various types of biodegradable particles and highly specialized particles, e.g. BNF (Bionized NanoFerrite) magnetic particles which are thermally blocked at room temperature or IDA latex with a very high binding capacity for trace metal ions. Special designed nanomag® particles possess unique surface properties combined with a high magnetomobility for a preferred use in nucleic acid separation. The fluorescent sicastar® and micromer® particles are also of interest to applications in Life Sciences because of their intense fluorescence activity and variable surface chemistry.

The production of particles is carried out according to proprietary synthesis schemes ranging from milliliter to bulk scale. A modern quality management system according to EN ISO 13485 combined with a sophisticated particle analysis system allows micromod to ensure its customers a high standard of quality in all product categories.

For more information visit our website: www.micromod.de.



Role of micromod within the "Dartrix Consortium"

Micromod provides magnetic nanoparticles with high and reproducible heating rates for the studies within the DARTRIX project. These particles will be conjugated to DARPin for selective targeting of cancer cells as requirement for the hyperthermia therapy. The particle production at micromod will be performed according to EN ISO 13485 under GMP conditions.




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